New research led by an Indian-origin scientist has found how protein that collects in the brain of persons with Alzheimer’s disease penetrates the cell membranes.
The findings, published in the Journal of Biological Chemistry, could lead to novel therapies for age-related diseases. The protein amyloid-beta builds up in the brains of persons with Alzheimer’s disease, ultimately aggregating into sticky clumps called plaque on the surface of neurons.
“From our study it is clear that the cell membrane is the hot spot where amyloid-beta becomes crazy,” said Ayyalusamy Ramamoorthy, professor at University of Michigan in the US.
